Protamine sulfate, a compound derived from purified fish sperm, is the antidote for heparin. It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin during delivery and heart surgery. Protamine sulfate is a medication that is used to reverse the effects of heparin. Guidelines may differ in other recommendations for heparin use. Guidelines recommend heparin as an appropriate choice for the treatment of acute proximal deep vein thrombosis or pulmonary embolism. Heparin is an anticoagulant (stops blood from clotting) and is used to treat and prevent blood clots occurring in the blood vessels or lungs. Protamine sulfate reverses the effect of unfractionated heparin completely and of low-molecular-weight heparin (LMWH) partially. What is the antidote for heparin and warfarin?įresh frozen plasma or prothrombin complex concentrate (PCC) may be necessary in major bleeding related to warfarin. The dose of protamine is based on the amount of heparin administered in the previous 2 hours using Table 2.

If immediate reversal is required protamine sulfate will result in neutralization of heparin.

Termination of the IV infusion generally will terminate the anticoagulant effect.

Thromboplastin (a commercial one and that obtained from different tissues) is shown to inactivate heparin in proportion to the quantity of thromboplastin or to the heparin:thromboplastin ratio.īeyond the obvious type A pharmacological toxicity, heparin products carry a seemingly paradoxical/novel risk of increased coagulopathy with limb- and life-threatening thromboembolic injuries (heparin-induced thrombocytopenia ). FFP (fresh frozen plasma) How do you inactivate heparin?

Heparin can be neutral- ized by protamine, and warfarin anticoagulation can be reversed by vitamin K injections. Traditional anticoagulants have antidotes. It may be used in those who overdose on heparin or to reverse heparin’s effect when it is no longer needed.

Protamine sulfate has been given to counteract the anticoagulant effect of heparin (1 mg per 100 units of heparin that had been given over the past four hours). What medications should not be taken with heparin?ĭrug interactions of heparin include medications that increase the risk of bleeding such as aspirin, clopidogrel, warfarin, other anticoagulants, and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, diclofenac, and others, because these add to the effects of heparin and further increase the … The toxicology of protamine depends on a complex interaction of the high molecular weight, a cationic peptide with the surfaces of the vasculature and blood cells. 5 What is the antidote for heparin and warfarin?Įxpert opinion: Despite of the low therapeutic index, protamine is the only registered antidote of heparins.2 What medications should not be taken with heparin?.

Antidote for heparin